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Ronidazole



Molecular Formula:C6H8N4O4
Molecular Weight:200.153
CAS Registry No: 7681-76-7
Systematic Name:
  • 1-Methyl-5-nitro-1H-imidazole-2-methanol carbamate ester (9CI)
  • 1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester)
  • Ronidazole
StorageRonidazole should be protected from light
Shelf Life2 year(s)
Specification
Appearance a white to yellowish brown powder; odourless or almost odourless
Solubility slightly soluble in water, in chloroform and in ethanol (96%); very slightly soluble in ether
Identification a) The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of ronidazole
b) The light absorption, Appendix II B, in the range 230 to 350 nm of a 0.002% w/v solution in 0.1M methanolic hydrochloric acid exhibits a maximum only at 270 nm. The absorbance at the maximum is about 0.64
c) Melting point, about 167X, Appendix V A.
Colour of solution not more intense than the spot 0.5%
Water
Not more than 0.5% w
w, Appendix IX C. Use 5 g
Sulphated ash Not more than 0.1%
Assaynot less than 98.5% and not more than 101.0%
1)calculated with reference to the anhydrous substance
Pharmacopoeial QualityEP