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Penicillamine



Molecular Formula: C5H11NO2S
Molecular Weight:149.213
CAS Registry No: 52-67-5
Systematic Name:
  • D-Penicillamine
  • D-Valine, 3-mercapto-
  • Penicillamine
  • Valine, 3-mercapto-, D-
StoragePreserve in tight containers
Shelf Life2 year(s)
Specification
Appearance white or practically white, crystalline powder, having a slight, characteristic odor
Solubility freely soluble in water; slightly soluble in alcohol; insoluble in chloroform and in ether.
Identification a) Infrared Absorption
b) Dissolve 10 mg in 5 mL of water, and add 1 drop of 5 N sodium hydroxide and 20 mg of ninhydrin: a blue or violet-blue color is produced immediately.
c) Dissolve 20 mg in 4 mL of water, add 2 mL of phosphotungstic acid solution (1 in 10), and heat nearly to boiling: a deep blue color is produced immediately
Specific rotation between 60.5 and 64.5
pHbetween 4.5 and 5.5, in a solution
Loss on drying Dry about 100 mg, accurately weighed, in a capillary-stoppered bottle in vacuum at a pressure not exceeding 5 mm of mercury at 60 for 3 hours
Residue on ignition not more than 0.1%
Heavy metalsnot more than 0.002%
Assaynot less than 97.0% and not more than 102.0%
1)calculated on the dried basis
Pharmacopoeial QualityUSP