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Tetracosactide acetate



Molecular Formula:C136H210N40O31S
Molecular Weight:2933.47
CAS Registry No: 16960-16-0
Systematic Name:
  • Tetracosactide
  • alpha(sup 1-24)-Corticotropin
  • alpha1-24-Corticotropin
StorageStore under nitrogen, protected from light, at a temperature between 2C and 8C
Shelf Life2 year(s)
Specification
Appearance a white or yellow, amorphous powder
Solubility sparingly soluble in water
Identification a) it increases the amount of corticosterone produced by isolated rat adrenal cells in the conditions of the assay
b) examine by electrophoresis and thin-layer chromatography
Specific optical rotation-99C to -109C
Absorbancethe absorbance at the maximum is 0.51 to 0.61, calculated with reference to the anhydrous, acetic acid-free substance
the ratio of the absorbance at the maximum at 276 nm to the absorbance at 248 nm is 2.4 to 2.9
Amino acidslysine: 3.5 to 4.7
histidine: 0.9 to 1.1
arginine: 2.7 to 3.3
serine: 1.1 to 2.2
glutamic acid: 0.9 to 1.1
proline: 2.5 to 3.5
glycine: 1.8 to 2.2
methionine: 0.9 to 1.1
tyrosine: 1.7 to 2.2
phenylalanine: 0.9 to 1.1
valine: 2.7 to 3.3
threonine: detected
Related peptideslargest single impurity: not more than 2.5%
total impurities: not more than 5.0%
Peptidenot less than 85.0%
Acetic acid8.0% to 13.0%
Water 5.0% to 16.0%
Potency
nto less than 800IU
mg
1)calculated with reference to the anhydrous, acetic acid-free substance
RemarkNone
Pharmacopoeial QualityEP